Guennadi Kozlov

PhD



SCIENTIFIC PUBLICATIONS

1. Kozlov, G. V.; Ogawa, M. Y. Electron-Transfer Across a Peptide-Peptide Interface Within a Designed Metalloprotein J. Am. Chem. Soc. 1997, 119, 8377-8378.

2. Fernando, S. R. L.; Kozlov, G. V.; Ogawa, M. Y. Distance Dependence of Electron Transfer Along Artificial beta-Strands at 298 and 77 K Inorg. Chem. 1998, 37, 1900-1905.

3. Kozlov, G.; Gehring, K.; Ekiel, I. Solution Structure of the PDZ2 Domain from Human Phosphatase hPTP1E and Its Interactions with C-Terminal Peptides from the Fas Receptor Biochemistry 2000, 39, 2572-2580.

4. Kozlov, G.; Ekiel, I.; Beglova, N.; Yee, A.; Dharamsi, A.; Engel, A.; Siddiqui, N.; Nong, A.; Gehring, K. Rapid Fold and Structure Determination of the Archaeal Translation Elongation Factor 1beta from Methanobacterium thermoautotrophicum J. Biomol. NMR 2000, 17, 187-194.

5. Christendat, D.; Yee, A.; Dharamsi, A.; Kluger, Y.; Savchenko, A.; Cort, J. R.; Booth, V.; Mackereth, C. D.; Saridakis, V.; Ekiel, I.; Kozlov, G.; Maxwell, K. L.; Wu, N.; McIntosh, L. P.; Gehring, K.; Kennedy, M. A.; Davidson, A. R.; Pai, E. F.; Gerstein, M.; Edwards, A. M.; Arrowsmith, C. H. Structural Proteomics of an Archaeon Nat. Struct. Biol. 2000, 7, 903-909.

6. Kozlov, G.; Trempe, J.-F.; Khaleghpour, K.; Kahvejian, A.; Ekiel, I.; Gehring, K. Structure and Function of the C-Terminal PABC Domain of Human Poly(A) Binding Protein Proc. Natl. Acad. Sci. USA 2001, 98, 4409-4413.

7. Kozlov, G.; Lee, J.; Gravel, M.; Ekiel, I.; Braun, P. E.; Gehring, K. Assignment of the 1H, 13C and 15N Resonances of the Catalytic Domain of the Rat 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase J. Biomol. NMR 2002, 22, 99-100.

8. Kozlov, G.; Siddiqui, N.; Coillet-Matillon, S.; Trempe, J. F.; Ekiel, I.; Sprules, T.; Gehring, K. Solution Structure of the Orphan PABC Domain from Saccharomyces cerevisiae Poly(A)-binding Protein J. Biol. Chem. 2002, 277, 22822-22828.

9. Yee, A., Chang, X., Pineda-Lucena, A., Wu, B., Semesi, A., Le, B., Ramelot, T., Lee, G.M., Bhattacharyya, S., Gutierrez, P., Denisov, A., Lee, C.H., Cort, J.R., Kozlov, G., Liaoi, J., Finak, G., Chen, L., Wishart, D., Lee, W., McIntosh, L.P., Gehring, K., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H. An NMR Approach to Structural Proteomics Proc. Natl. Acad. Sci. USA 2002, 99, 1825-1830.

10. Kozlov, G.; Banville, D.; Gehring, K.; Ekiel, I. Solution Structure of the PDZ2 Domain from Cytosolic Human Phosphatase hPTP1E Complexed with a Peptide Reveals Contribution of the beta2- beta3 Loop to PDZ Domain-Ligand Interactions J. Mol. Biol. 2002, 320, 813-820.

11. Kozlov, G.; Chen, J.; Lievre, C.; Banville, D.; Gehring, K.; Ekiel, I. 1H, 13C and 15N Resonance Assignments of the Human Phosphatase PRL-3 J. Biomol. NMR 2002, 24, 169-170.

12. Siddiqui N, Kozlov G, D'Orso I, Trempe JF, Gehring K. Solution structure of the C-terminal domain from poly(A)-binding protein in Trypanosoma cruzi: a vegetal PABC domain Protein Sci. 2003, 12, 1925-1933.

13. Kozlov G, Lee J, Elias D, Gravel M, Gutierrez P, Ekiel I, Braun PE, Gehring K. Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily J. Biol. Chem. 2003, 278, 46021-46028.

14. Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase EMBO J. 2004, 23, 272-281.

15. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I. Structural insights into molecular function of the metastasis associated phosphatase PRL-3 J. Biol. Chem. 2004, 279, 11882-11889.

16. Pollock S, Kozlov G, Pelletier MF, Trempe JF, Jansen G, Sitnikov D, Bergeron JJ, Gehring K, Ekiel I, Thomas DY. Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system EMBO J. 2004, 23, 1020-1029.

17. Kozlov G, Elias D, Cygler M, Gehring K. Structure of GlgS from Escherichia coli suggests a role in protein-protein interactions BMC Biol. 2004, 2, 10.

18. Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I. Insights into function of PSI domains from structure of the Met receptor PSI domain Biochem. Biophys. Res. Commun. 2004, 321, 234-240.

19. Kozlov G, Elias D, Semesi A, Yee A, Cygler M, Gehring K. Structural similarity of YbeD protein from Escherichia coli to allosteric regulatory domains J Bacteriol. 2004, 186, 8083-8088.

20. Kozlov G, Vavelyuk O, Minailiuc O, Banville O, Gehring K, Ekiel I. Solution structure of a two-repeat fragment of major vault protein J. Mol. Biol. 2006, 356, 444-452.

21. Lim NS, Kozlov G, Chang TC, Groover O, Siddiqui N, Volpon L, De Crescenzo G, Shyu AB, Gehring K. Comparative peptide-binding studies of PABC domains from the E3 ubiquitin ligase HYD and poly(A)-binding protein: implications for HYD function J. Biol. Chem. 2006, 281, 14376-14382.

22. Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J. 2006, 25, 1934-1944.

23. Kozlov G, Maattanen P, Schrag JD, Pollock S, Cygler M, Nagar B, Thomas DY, Gehring K. Crystal Structure of the bb' Domains of the Protein Disulfide Isomerase ERp57. Structure 2006, 14, 1331-1339.

24. Denisov AY, Kozlov G, Gravel M, Sprules T, Braun PE, Gehring K. 1H, 13C and 15N resonance assignments of the catalytic domain of the goldfish RICH protein. J. Biomol. NMR 2006, 36, Suppl.5, 75.

25. Maattanen P, Kozlov G, Gehring K, Thomas DY. ERp57 and PDI: multifuctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations. Biochem. Cell Biol. 2006, 84, 881-889.

26. Denisov AY, Sprules T, Fraser J, Kozlov G, Gehring K. Heat-induced dimerization of BCL-xL through alpha-helix swapping. Biochemistry 2007, 46, 734-740.

27. Kozlov G, Denisov AY, Pomerantseva E, Gravel M, Braun PE, Gehring K. Solution structure of the catalytic domain of RICH protein from goldfish. FEBS J. 2007, 274, 1600-1609.

28. Gutierrez P, Kozlov G, Gabrielli L, Elias D, Osborne MJ, Gallouzi I.E., Gehring K. Solution structure of YaeO: a Rho-specific inhibitor of transcription termination. J. Biol. Chem. , 2007, 282, 23348-23353.

29. Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M. Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J. Biol. Chem. , 2007, 282, 27547-27555.

30. Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K. Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol. Cell, 2007, 27, 474-485.

31. Kozlov G, Nguyen L, Lin T, De Crescenzo G, Park M, Gehring K. Structural basis of ubiquitin recognition by the UBA domain of the ubiquitin ligase EDD. J. Biol. Chem. , 2007, 282, 35787-35795.

32. Nguyen L, Kozlov G, Gehring K. Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding. FEBS Lett. , 2008, 582, 623-626.

33. Matta-Camacho E, Kozlov G, Trempe JF, Gehring K. Atypical Binding of the Swa2p UBA Domain to Ubiquitin. J. Mol. Biol. , 2009, 386, 569-577.

34. Denisov AY, Maattanen P, Dabrowski C, Kozlov G, Thomas DY, Gehring K. Solution structure of the bb' domains of human protein disulfide isomerase. FEBS J. , 2009, 276, 1440-1449.

35. Kozlov G, Maattanen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K. Structure of the non-catalytic domains and global fold of the protein disulfide isomerase ERp72. Structure , 2009, 17, 651-659.

36. Zhang Y, Kozlov G, Pocanschi CL, Brockmeier U, Ireland BS, Maattanen P, Howe C, Elliott T, Gehring K, Williams DB. ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility moleculers and it enhances peptide loading independently of its redox activity. J. Biol. Chem. , 2009, 284, 10160-10173.


Contact: guennadi.kozlov@mcgill.ca