PIMA Multiple Sequence Alignment Results

Maximal Linkage Clustering

pat-ML ((((ataxin2 6475.34 ataxin2.2) 5724.77 mataxin) 3941.10 SCA2) 1520.51 ataxin2.1)



Page 1.1
                1            15 16           30 31           45 46           60 61           75 76           90 
    1 pat-ML    --------------- --------------- --------------- --------------- --------------- ---------------      0

    2 ataxin2   --------------- --------------- --------------- -----MRSAAAAPRS PAVATESRR---FAA ARWPGWRSLQRPARR     37
    3 ataxin2.2 PRESNPARRPLLTCP SRPRGHLTFCFRLTP PTSGKESLSAPPLPP GASARPPSDALSGRS SSESRGGHRVSPFAA ARWPGWRSLQRPARR     90
    4 mataxin   --------------- --------------- --------------- ----MRSSTAAVQRP AAGDPEPRR-----P AGWAARRSLPRTARR     36
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------      0
    6 ataxin2.1 --------------- --------------- --------------- --------------- --------------- ---------------      0



Page 2.1
                91          105 106         120 121         135 136         150 151         165 166         180 
    1 pat-ML    --------------- --------------- -------------hr jjjgggRjhSrRggf LjXXjjPRjgggggg ggggggjPjAjPjXj     47

    2 ataxin2   SGRGGGGAAPGPYPS AAPPPPGPGPPPSRQ SSPPSASDCFGSNGN GGGA-FRPGSRR--L LGLGGPPRPFVVVLL PLASPGAPPAAPTRA    124
    3 ataxin2.2 SGRGGGGAAPGPYPS AALPPPGPGPPPSRQ SSPPSASDCFGSNGN GGGA-FRPGSRR--L LGLGGPPRPFVVLLL PLASPGAPPAAPTRA    177
    4 mataxin   GGRGGAVA----YPS AGPPPRGPGAPPRGP RSPPCASDCFGSNGH GAS---RPGSRR--L LGVCGPPRPFVVVLL AL----APAATPARA    113
    5 SCA2      --------------- --------------- -------------GN GGGA-FRPGSRR--L LGLGGPPRPFVVVLL PLASPGAPPAAPTRA     44
    6 ataxin2.1 --------------- -------------MG WRPGRDAPHFPPAAR PPPLPPRGASSRRGF LSPPPTPRG------ ---SPRPPTAGPGCP     53



Page 3.1
                181         195 196         210 211         225 226         240 241         255 256         270 
    1 pat-ML    XPXhXRAggrjPrjG XgSXjXXjXjgPrjX CrXVXhjXjXiXXPX Xgggggggggggggg gggggggjPjjjrXr rPggGGggGXLjijh    137

    2 ataxin2   SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    208
    3 ataxin2.2 SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    261
    4 mataxin   CPPGVRA--SPPRSG VSSSARPAPGCPRPA CEPVYGPLTMSLKPQ PQ------------- -------PPAPATGR KP--GG--GLLSSPG    177
    5 SCA2      SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    128
    6 ataxin2.1 IPLASRALQRGPSPG PLSPSLLSNS-PSGR CHHVEASAATTALPA P------------AA APHATCRGPSAPRGH SPPNGGLPGPLATSA    130



Page 4.1
                271         285 286         300 301         315 316         330 331         345 346         360 
    1 pat-ML    AjggPjjggggggjj VjjjjgggXXhjXjX cAjrjgggggggggg GhhXXGXhRGpriXK GXPQjjagFkGaYXN XRMcHfLTjVVGSrC    227

    2 ataxin2   AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    279
    3 ataxin2.2 AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    332
    4 mataxin   AA--PAS------AA VTSASV--VPAPAAP VASSSA-------AA GGGRPGLGRGRNSSK GLPQPTISFDGIYAN VRMVHILTSVVGSKC    250
    5 SCA2      AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    199
    6 ataxin2.1 APPGPPAAASPCLGP VAAAGSGLRRGAEGI LAPQPPPPQQHQERP GAAAIGSARGQSTGK GPPQSPV-FEGVYNN SRMLHFLTAVVGSTC    219



Page 5.1
                361         375 376         390 391         405 406         420 421         435 436         450 
    1 pat-ML    kVpVKNGjXYEGaFK TfSjKfkLXcDAXHp KjiEjjjGPnREkIc kiccFKXSDfccVrF nlXDXrYArnDXFTD SAcjggjKVNGEHKE    317

    2 ataxin2   EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    367
    3 ataxin2.2 EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    420
    4 mataxin   EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESVLFKCSDFVVVQF KDTDSSYARRDAFTD SALS--AKVNGEHKE    338
    5 SCA2      EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    287
    6 ataxin2.1 DVKVKNGTTYEGIFK TLSSKFELAVDAVHR KASEPAGGPRREDIV DTMVFKPSDVMLVHF RNVDFNYATKDKFTD SAIAMNSKVNGEHKE    309



Page 6.1
                451         465 466         480 481         495 496         510 511         525 526         540 
    1 pat-ML    KXLoXWkhGkgiXrk kfkgLErDcSNGWDP NkMFndNEENYGVXi TYDSSLSSYTVPLEn DNSEEFXpREXRAXQ LApEIESSjQYnXRa    407

    2 ataxin2   KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    457
    3 ataxin2.2 KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    510
    4 mataxin   KDLEPWDAGELTASE ELE-LENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    427
    5 SCA2      KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    377
    6 ataxin2.1 KVLQRWEGGD-SNSD DYD-LESDMSNGWDP NEMFKFNEENYGVKT TYDSSLSSYTVPLEK DNSEEFRQRELRAAQ LAREIESSPQYRLRI    397



Page 7.1
                541         555 556         570 571         585 586         600 601         615 616         630 
    1 pat-ML    AbENDDgRiEEEKei AVQRrXSXREjXjXX iRkXKYIPXjQRXRE gXjXGjXRXrSjRXG pPGXjSbPjRjjrHX rlXrPXjGSkXRXaN    497

    2 ataxin2   ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    546
    3 ataxin2.2 ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    599
    4 mataxin   ALENDD-RSEEEKYT AVQRNCSDREGHGPN TRDNKYIPPGQRNRE VLSWGSGRQSSPRMG QPGPGSMPSRAASHT SDFNPNAGSDQRVVN    516
    5 SCA2      ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    466
    6 ataxin2.1 AMENDDGRTEEEKHS AVQRQGSGRESPSLA SREGKYIPLPQRVRE -GPRGGVRCSSSRGG RPGLSSLPPRGPHHL DNSSPGPGSEARGIN    486



Page 8.1
                631         645 646         660 661         675 676         690 691         705 706         720 
    1 pat-ML    GGggggggggggggg gPSRgggggggbjPn AggggggggpXPXRj jnjXSrPSXrXXXXX fSTgggggSSXjjPr cSPnggggggggggg    587

    2 ataxin2   GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    636
    3 ataxin2.2 GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    689
    4 mataxin   GGVPWPSPCPSHSSR PPSRYQSGPNSLPPR AATHTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    606
    5 SCA2      GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    556
    6 ataxin2.1 GG------------- -PSR-------MSPK A--------QRPLRG AKTLSSPSNRLLENF CST-----SSCSGPD VSPR-----------    531



Page 9.1
                721         735 736         750 751         765 766         780 781         795 796         810 
    1 pat-ML    ggggggggggggggg gjPrrAAjjPggggg gggggggggaShggg ggggggggggggggS fjmjPXGjXcjijrA jIXXjrjVjXPgjXh    677

    2 ataxin2   AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    726
    3 ataxin2.2 AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    779
    4 mataxin   AGRGSMSSGLEFVSH NPPSEAAAPPVARTS PAGGTWSSVVSGVPR LSPKTHRPRSPRQSS IGNSPSGPVLASPQA GIIPAEAVSMPVPAA    696
    5 SCA2      AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    646
    6 ataxin2.1 --------------- -SPKSAAPAP----- ---------ISA--- --------------S CPEPPIGSAVPTSSA SIPVTSSVSDP-GVG    573



Page 10.1
                811         825 826         840 841         855 856         870 871         885 886         900 
    1 pat-ML    SXiPASPggrXjcjP ggggggircpkXrrr rPhgggprcpjrEXj XXXjKgggggcjjcX rErnngQckkLnKFX XrFnLQPSSijEgSb    767

    2 ataxin2   SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    814
    3 ataxin2.2 SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    867
    4 mataxin   SPTPASPASNRALTP SIEAKDSRLQDQRQN SPAGSKENVKASETS PSFSKADNKGMSPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    784
    5 SCA2      SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    734
    6 ataxin2.1 SISPASP--KISLAP ------TDVKELSTK EPG---RTLEPQELA RIAGK-----VPGLQ NEQKRFQLEELRKFG AQFKLQPSSSPENSL    647



Page 11.1
                901         915 916         930 931         945 946         960 961         975 976         990 
    1 pat-ML    DggggpcLrpmXpGg EKrXDgLcrrpXXjS jggggggggggSSrX rSXSrKXlrPjcjPS XXimjXrpXjPXfjS gggQTjSPjfXXXKX    857

    2 ataxin2   D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    896
    3 ataxin2.2 D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    949
    4 mataxin   D----QLLSKNREG- EKSRD-LIKDKTEAS AKDSFIDSSSSSSNC TSGSSKTNSPSISPS MLSNAEHKRGPEVTS QGVQTSSPACKQEKD    868
    5 SCA2      D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    816
    6 ataxin2.1 DPFPPRILKEEPKGK EKEVDGLLTSEPMGS P-------V--SSKT ESVSDKEDKPPLAPS GGTEGPEQPPPPCPS ---QTGSPPVGLIKG    725



Page 12.1
                991        1005 1006       1020 1021       1035 1036       1050 1051       1065 1066       1080 
    1 pat-ML    krpkpXXXjEQVnKS TLNPNAKEFNPrrgg fSXXKjiiTPTSPXP pjrjiPScggggggg PVfTggQjXfdjPrf cXXaPgggcjPhVQg    947
    
    2 ataxin2   DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQP    979
    3 ataxin2.2 DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQP   1032
    4 mataxin   DREEKKDTTEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPA PVYT--QPVCFAPNM MYPVP---VSPGVQP    951
    5 SCA2      DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQ-    898
    6 ataxin2.1 EDKDEGPVAEQVKKS TLNPNAKEFNPTKPL LSVNKSTSTPTSPGP RTHSTPSI------- PVLTAGQSGLYSPQY ISYIPQIHMGPAVQA    808



Page 13.1
                1081       1095 1096       1110 1111       1125 1126       1140 1141       1155 1156       1170 
    1 pat-ML    gggggYXaggggfPg rrhKgggfRgggggc P-------------- --------------- --------------- ---------------    978

    2 ataxin2   ----LYPIPMTPMPV NQAKT--YRA----V PNMPQQRQDQHHQSA MMHPASAAGPPIAAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1059
    3 ataxin2.2 ----LYPIPMTPMPV NQAKT--YRA----V PNMPQQRQDQHHQSA MMHPASAAGPPIAAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1112
    4 mataxin   ----LYPIPMTPMPV NQAKT--YRA--GKV PNMPQQRQDQHHQST MMHPASAAGPPIVAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1033
    5 SCA2      -----YQI----CP- NSGKTSIIR-----V P-------------- --------------- --------------- ---------------    914
    6 ataxin2.1 PQMYPYPV-SNSVPG QQGK---YRGAKGSL PPQRSDQHQPASAPP MMQAAAAAGPPLVAA TPYSSYIPYNPQQFP GQPAMMQPMAHYPSQ    894



Page 14.1
                1171       1185 1186       1200 1201       1215 1216       1230 1231       1245 1246       1260 
    1 pat-ML    --------------- --------------- --------------- --------------- --------------- ---------------    978

    2 ataxin2   QHPHVYSPVIQGNAR MMAPPTHAQPGLVSS SATQYGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNATLHPHTPHPQPS   1149
    3 ataxin2.2 QHPHVYSPVIQGNAR MMAPPTHAQPGLVSS SATQYGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNATLHPHTPHPQPS   1202
    4 mataxin   QHPHVYSPVIQGNAR MMAPPAHAQPGLVSS SAAQFGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNAALHPHTPHPQPS   1123
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------    914
    6 ataxin2.1 PVFAPMLQSNPRMLT SGSHPQAIVSSSTPQ YPSAEQPTPQALYAT VHQSYPHHATQLHAH QPQPATTPTGSQPQS QHAAPSPVQVPAMGG    984



Page 15.1
                1261       1275 1276       1290 1291       1305 1306       1320 1321       1335 1336       1350 
    1 pat-ML    --------------- --------------- --------------- --------------- --------------- ---------------    978

    2 ataxin2   ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQNSFPAAQQTV FTIHPSHVQPAYTNP   1239
    3 ataxin2.2 ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQNSFPAAQQTV FTIHPSHVQPAYTNP   1292
    4 mataxin   ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQSSFPAAQQTV FTIHPSHVQPAYTTP   1213
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------    914
    6 ataxin2.1 AEWSWCRNGWPEEGI ELGVISEWRGLGASE LLACVALNLPLPSSI RRGRPHTWAVDSHSR ICTTQGP-------- ---------------   1051



Page 16.1
                1351       1365 1366       1380 1381       1395 1396       1410 1411       1425 1426       1440 
    1 pat-ML    --------------- --------------- --------------- --------------- -------------    978

    2 ataxin2   PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPPGGPQAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1312
    3 ataxin2.2 PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPPGGPQAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1365
    4 mataxin   PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPP-GPKAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1285
    5 SCA2      --------------- --------------- --------------- --------------- -------------    914
    6 ataxin2.1 --------------- --------------- --------------- --------------- -------------   1051

Sequential Branching Clustering

pat-SB ((((ataxin2 6475.34 ataxin2.2) 5761.44 mataxin) 4495.35 SCA2) 1945.00 ataxin2.1)



Page 1.1
                1            15 16           30 31           45 46           60 61           75 76           90 
    1 pat-SB    --------------- --------------- --------------- --------------- --------------- ---------------      0

    2 ataxin2   --------------- --------------- --------------- -----MRSAAAAPRS PAVATESRR---FAA ARWPGWRSLQRPARR     37
    3 ataxin2.2 PRESNPARRPLLTCP SRPRGHLTFCFRLTP PTSGKESLSAPPLPP GASARPPSDALSGRS SSESRGGHRVSPFAA ARWPGWRSLQRPARR     90
    4 mataxin   --------------- --------------- --------------- ----MRSSTAAVQRP AAGDPEPRR-----P AGWAARRSLPRTARR     36
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------      0
    6 ataxin2.1 --------------- --------------- --------------- --------------- --------------- ---------------      0



Page 2.1
                91          105 106         120 121         135 136         150 151         165 166         180 
    1 pat-SB    --------------- --------------- -------------hr jjjgggRjhSrRggf LjXXjjPRjgggggg ggggggjPjAjPjXj     47

    2 ataxin2   SGRGGGGAAPGPYPS AAPPPPGPGPPPSRQ SSPPSASDCFGSNGN GGGA-FRPGSRR--L LGLGGPPRPFVVVLL PLASPGAPPAAPTRA    124
    3 ataxin2.2 SGRGGGGAAPGPYPS AALPPPGPGPPPSRQ SSPPSASDCFGSNGN GGGA-FRPGSRR--L LGLGGPPRPFVVLLL PLASPGAPPAAPTRA    177
    4 mataxin   GGRGGAVA----YPS AGPPPRGPGAPPRGP RSPPCASDCFGSNGH GAS---RPGSRR--L LGVCGPPRPFVVVLL AL----APAATPARA    113
    5 SCA2      --------------- --------------- -------------GN GGGA-FRPGSRR--L LGLGGPPRPFVVVLL PLASPGAPPAAPTRA     44
    6 ataxin2.1 --------------- -------------MG WRPGRDAPHFPPAAR PPPLPPRGASSRRGF LSPPPTPRG------ ---SPRPPTAGPGCP     53



Page 3.1
                181         195 196         210 211         225 226         240 241         255 256         270 
    1 pat-SB    XPXhXRAggrjPrjG XgSXjXXjXjgPrjX CrXVXhjXjXiXXPX Xgggggggggggggg gggggggjPjjjrXr rPggGGggGXLjijh    137

    2 ataxin2   SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    208
    3 ataxin2.2 SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    261
    4 mataxin   CPPGVRA--SPPRSG VSSSARPAPGCPRPA CEPVYGPLTMSLKPQ PQ------------- -------PPAPATGR KP--GG--GLLSSPG    177
    5 SCA2      SPLGARA--SPPRSG V-SLARPAPGCPRPA CEPVYGPLTMSLKPQ QQQQQQQQQQQQQQQ QQQQQQPPPAAANVR KP--GGS-GLLASPA    128
    6 ataxin2.1 IPLASRALQRGPSPG PLSPSLLSNS-PSGR CHHVEASAATTALPA P------------AA APHATCRGPSAPRGH SPPNGGLPGPLATSA    130



Page 4.1
                271         285 286         300 301         315 316         330 331         345 346         360 
    1 pat-SB    AjggPjjggggggjj VjjjjgggXXhjXjX cAjrjgggggggggg GhhXXGXhRGpriXK GXPQjjagFkGaYXN XRMcHfLTjVVGSrC    227

    2 ataxin2   AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    279
    3 ataxin2.2 AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    332
    4 mataxin   AA--PAS------AA VTSASV--VPAPAAP VASSSA-------AA GGGRPGLGRGRNSSK GLPQPTISFDGIYAN VRMVHILTSVVGSKC    250
    5 SCA2      AAPSPSS------SS VSSSS---ATAPSSV VAATS---------- GGGRPGLGRGRNSNK GLPQSTISFDGIYAN MRMVHILTSVVGSKC    199
    6 ataxin2.1 APPGPPAAASPCLGP VAAAGSGLRRGAEGI LAPQPPPPQQHQERP GAAAIGSARGQSTGK GPPQSPV-FEGVYNN SRMLHFLTAVVGSTC    219



Page 5.1
                361         375 376         390 391         405 406         420 421         435 436         450 
    1 pat-SB    kVpVKNGjXYEGaFK TfSjKfkLXcDAXHp KjiEjjjGPnREkIc kiccFKXSDfccVrF nlXDXrYArnDXFTD SAcjggjKVNGEHKE    317

    2 ataxin2   EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    367
    3 ataxin2.2 EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    420
    4 mataxin   EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESVLFKCSDFVVVQF KDTDSSYARRDAFTD SALS--AKVNGEHKE    338
    5 SCA2      EVQVKNGGIYEGVFK TYSPKCDLVLDAAHE KSTESSSGPKREEIM ESILFKCSDFVVVQF KDMDSSYAKRDAFTD SAIS--AKVNGEHKE    287
    6 ataxin2.1 DVKVKNGTTYEGIFK TLSSKFELAVDAVHR KASEPAGGPRREDIV DTMVFKPSDVMLVHF RNVDFNYATKDKFTD SAIAMNSKVNGEHKE    309



Page 6.1
                451         465 466         480 481         495 496         510 511         525 526         540 
    1 pat-SB    KXLoXWkhGkgiXrk kfkgLErDcSNGWDP NkMFndNEENYGVXi TYDSSLSSYTVPLEn DNSEEFXpREXRAXQ LApEIESSjQYnXRa    407

    2 ataxin2   KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    457
    3 ataxin2.2 KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    510
    4 mataxin   KDLEPWDAGELTASE ELE-LENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    427
    5 SCA2      KDLEPWDAGELTANE ELEALENDVSNGWDP NDMFRYNEENYGVVS TYDSSLSSYTVPLER DNSEEFLKREARANQ LAEEIESSAQYKARV    377
    6 ataxin2.1 KVLQRWEGGD-SNSD DYD-LESDMSNGWDP NEMFKFNEENYGVKT TYDSSLSSYTVPLEK DNSEEFRQRELRAAQ LAREIESSPQYRLRI    397



Page 7.1
                541         555 556         570 571         585 586         600 601         615 616         630 
    1 pat-SB    AbENDDgRiEEEKei AVQRrXSXREjXjXX iRkXKYIPXjQRXRE gXjXGjXRXrSjRXG pPGXjSbPjRjjrHX rlXrPXjGSkXRXaN    497

    2 ataxin2   ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    546
    3 ataxin2.2 ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    599
    4 mataxin   ALENDD-RSEEEKYT AVQRNCSDREGHGPN TRDNKYIPPGQRNRE VLSWGSGRQSSPRMG QPGPGSMPSRAASHT SDFNPNAGSDQRVVN    516
    5 SCA2      ALENDD-RSEEEKYT AVQRNSSEREGHSIN TRENKYIPPGQRNRE VISWGSGRQNSPRMG QPGSGSMPSRSTSHT SDFNPNSGSDQRVVN    466
    6 ataxin2.1 AMENDDGRTEEEKHS AVQRQGSGRESPSLA SREGKYIPLPQRVRE -GPRGGVRCSSSRGG RPGLSSLPPRGPHHL DNSSPGPGSEARGIN    486



Page 8.1
                631         645 646         660 661         675 676         690 691         705 706         720 
    1 pat-SB    GGggggggggggggg gPSRgggggggbjPn AggggggggpXPXRj jnjXSrPSXrXXXXX fSTgggggSSXjjPr cSPnggggggggggg    587

    2 ataxin2   GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    636
    3 ataxin2.2 GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    689
    4 mataxin   GGVPWPSPCPSHSSR PPSRYQSGPNSLPPR AATHTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    606
    5 SCA2      GGVPWPSPCPSPSSR PPSRYQSGPNSLPPR AATPTRPPSRPPSRP SRPPSHPSAHGSPAP VSTMPKRMSSEGPPR MSPKAQRHPRNHRVS    556
    6 ataxin2.1 GG------------- -PSR-------MSPK A--------QRPLRG AKTLSSPSNRLLENF CST-----SSCSGPD VSPR-----------    531



Page 9.1
                721         735 736         750 751         765 766         780 781         795 796         810 
    1 pat-SB    ggggggggggggggg gjPrrAAjjPggggg gggggggggaShggg ggggggggggggggS fjmjPXGjXcjijrA jIXXjrjVjXPgjXh    677

    2 ataxin2   AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    726
    3 ataxin2.2 AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    779
    4 mataxin   AGRGSMSSGLEFVSH NPPSEAAAPPVARTS PAGGTWSSVVSGVPR LSPKTHRPRSPRQSS IGNSPSGPVLASPQA GIIPAEAVSMPVPAA    696
    5 SCA2      AGRGSISSGLEFVSH NPPSEAATPPVARTS PSGGTWSSVVSGVPR LSPKTHRPRSPRQNS IGNTPSGPVLASPQA GIIPTEAVAMPIPAA    646
    6 ataxin2.1 --------------- -SPKSAAPAP----- ---------ISA--- --------------S CPEPPIGSAVPTSSA SIPVTSSVSDP-GVG    573



Page 10.1
                811         825 826         840 841         855 856         870 871         885 886         900 
    1 pat-SB    SXiPASPggrXjcjP ggggggircpkXrrr rPhgggprcpjrEXj XXXjKgggggcjjcX rErnngQckkLnKFX XrFnLQPSSijEgSb    767

    2 ataxin2   SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    814
    3 ataxin2.2 SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    867
    4 mataxin   SPTPASPASNRALTP SIEAKDSRLQDQRQN SPAGSKENVKASETS PSFSKADNKGMSPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    784
    5 SCA2      SPTPASPASNRAVTP SSEAKDSRLQDQRQN SPAGNKENIKPNETS PSFSKAENKGISPVV SEHRK-QIDDLKKFK NDFRLQPSSTSE-SM    734
    6 ataxin2.1 SISPASP--KISLAP ------TDVKELSTK EPG---RTLEPQELA RIAGK-----VPGLQ NEQKRFQLEELRKFG AQFKLQPSSSPENSL    647



Page 11.1
                901         915 916         930 931         945 946         960 961         975 976         990 
    1 pat-SB    DggggpcLrpmXpGg EKrXDgLcrrpXXjS jggggggggggSSrX rSXSrKXlrPjcjPS XXimjXrpXjPXfjS gggQTjSPjfXXXKX    857

    2 ataxin2   D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    896
    3 ataxin2.2 D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    949
    4 mataxin   D----QLLSKNREG- EKSRD-LIKDKTEAS AKDSFIDSSSSSSNC TSGSSKTNSPSISPS MLSNAEHKRGPEVTS QGVQTSSPACKQEKD    868
    5 SCA2      D----QLLNKNREG- EKSRD-LIKDKIEPS AKDSFIE--NSSSNC TSGSSKPNSPSISPS ILSNTEHKRGPEVTS QGVQTSSPACKQEKD    816
    6 ataxin2.1 DPFPPRILKEEPKGK EKEVDGLLTSEPMGS P-------V--SSKT ESVSDKEDKPPLAPS GGTEGPEQPPPPCPS ---QTGSPPVGLIKG    725



Page 12.1
                991        1005 1006       1020 1021       1035 1036       1050 1051       1065 1066       1080 
    1 pat-SB    krpkpXXXjEQVnKS TLNPNAKEFNPrrgg fSXXKjiiTPTSPXP pjrjiPScggggggg PVfTggQjXfdjPrf cXXaPgggcjPhVQg    947
    
    2 ataxin2   DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQP    979
    3 ataxin2.2 DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQP   1032
    4 mataxin   DREEKKDTTEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPA PVYT--QPVCFAPNM MYPVP---VSPGVQP    951
    5 SCA2      DKEEKKDAAEQVRKS TLNPNAKEFNPRS-- FSQPKPSTTPTSPRP QAQPSPSMVGHQQPT PVYT--QPVCFAPNM MYPVP---VSPGVQ-    898
    6 ataxin2.1 EDKDEGPVAEQVKKS TLNPNAKEFNPTKPL LSVNKSTSTPTSPGP RTHSTPSI------- PVLTAGQSGLYSPQY ISYIPQIHMGPAVQA    808



Page 13.1
                1081       1095 1096       1110 1111       1125 1126       1140 1141       1155 1156       1170 
    1 pat-SB    gggggYXaggggfPg rrhKgggfRgggggc P-------------- --------------- --------------- ---------------    978

    2 ataxin2   ----LYPIPMTPMPV NQAKT--YRA----V PNMPQQRQDQHHQSA MMHPASAAGPPIAAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1059
    3 ataxin2.2 ----LYPIPMTPMPV NQAKT--YRA----V PNMPQQRQDQHHQSA MMHPASAAGPPIAAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1112
    4 mataxin   ----LYPIPMTPMPV NQAKT--YRA--GKV PNMPQQRQDQHHQST MMHPASAAGPPIVAT PPAYSTQYVAYSPQQ FPNQPLVQHVPHYQS   1033
    5 SCA2      -----YQI----CP- NSGKTSIIR-----V P-------------- --------------- --------------- ---------------    914
    6 ataxin2.1 PQMYPYPV-SNSVPG QQGK---YRGAKGSL PPQRSDQHQPASAPP MMQAAAAAGPPLVAA TPYSSYIPYNPQQFP GQPAMMQPMAHYPSQ    894



Page 14.1
                1171       1185 1186       1200 1201       1215 1216       1230 1231       1245 1246       1260 
    1 pat-SB    --------------- --------------- --------------- --------------- --------------- ---------------    978

    2 ataxin2   QHPHVYSPVIQGNAR MMAPPTHAQPGLVSS SATQYGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNATLHPHTPHPQPS   1149
    3 ataxin2.2 QHPHVYSPVIQGNAR MMAPPTHAQPGLVSS SATQYGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNATLHPHTPHPQPS   1202
    4 mataxin   QHPHVYSPVIQGNAR MMAPPAHAQPGLVSS SAAQFGAHEQTHAMY ACPKLPYNKETSPSF YFAISTGSLAQQYAH PNAALHPHTPHPQPS   1123
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------    914
    6 ataxin2.1 PVFAPMLQSNPRMLT SGSHPQAIVSSSTPQ YPSAEQPTPQALYAT VHQSYPHHATQLHAH QPQPATTPTGSQPQS QHAAPSPVQVPAMGG    984



Page 15.1
                1261       1275 1276       1290 1291       1305 1306       1320 1321       1335 1336       1350 
    1 pat-SB    --------------- --------------- --------------- --------------- --------------- ---------------    978

    2 ataxin2   ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQNSFPAAQQTV FTIHPSHVQPAYTNP   1239
    3 ataxin2.2 ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQNSFPAAQQTV FTIHPSHVQPAYTNP   1292
    4 mataxin   ATPTGQQQSQHGGSH PAPSPVQHHQHQAAQ ALHLASPQQQSAIYH AGLAPTPPSMTPASN TQSPQSSFPAAQQTV FTIHPSHVQPAYTTP   1213
    5 SCA2      --------------- --------------- --------------- --------------- --------------- ---------------    914
    6 ataxin2.1 AEWSWCRNGWPEEGI ELGVISEWRGLGASE LLACVALNLPLPSSI RRGRPHTWAVDSHSR ICTTQGP-------- ---------------   1051



Page 16.1
                1351       1365 1366       1380 1381       1395 1396       1410 1411       1425 1426       1440 
    1 pat-SB    --------------- --------------- --------------- --------------- -------------    978

    2 ataxin2   PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPPGGPQAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1312
    3 ataxin2.2 PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPPGGPQAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1365
    4 mataxin   PHMAHVPQAHVQSGM VPSHPTAHAPMMLMT TQPP-GPKAALAQSA LQPIPVSTTAHFPYM THPSVQAHHQQQL   1285
    5 SCA2      --------------- --------------- --------------- --------------- -------------    914
    6 ataxin2.1 --------------- --------------- --------------- --------------- -------------   1051