PIMA Multiple Sequence Alignment Results

Maximal Linkage Clustering

pat-ML (((TOB2 1582.00 mTOB2) 1434.00 TOB) 952.53 (TOB1 1626.05 mTOB1))



Page 1.1
             1            15 16           30 31           45 46           60 61           75 76           90 
    1 pat-ML MQLEIpVALNFIISY LYNKLPRRRXlcFGE ELEpXLnKKYEGHWY PEKPfKGSGFRCaHa GEXVDPVaEXAjKpS GLXakDVRhNcPokL     90

    2 TOB2   MQLEIKVALNFIISY LYNKLPRRRADLFGE ELERLLKKKYEGHWY PEKPLKGSGFRCVHI GEMVDPVVELAAKRS GLAVEDVRANVPEEL     90
    3 mTOB2  MQLEIKVALNFIISY LYNKLPRRRADLFGE ELERLLRKKYEGHWY PEKPLKGSGFRCVHI GEVVDPVVELAAKRS GLAVEDVRANVPEEL     90
    4 TOB    MQLEIKVALNFIISY LYNKLPRRRADLFGE ELEQALKKKYEGHWY PEKPLKGSGFRCVHI GEMVDPVVELAAKRS GLAVEDVRANVPEEL     90
    5 TOB1   MQLEIQVALNFIISY LYNKLPRRRVNIFGE ELERLLKKKYEGHWY PEKPYKGSGFRCIHI GEKVDPVIEQASKES GLDIDDVRGNLPQDL     90
    6 mTOB1  MQLEIQVALNFIISY LYNKLPRRRVNIFGE ELERLLKKKYEGHWY PEKPYKGSGFRCIHV GEKVDPVIEQASKES GLDIDDVRGNLPQDL     90



Page 2.1
             91          105 106         120 121         135 136         150 151         165 166         180 
    1 pat-ML SVWIDPFEVSYQIGE KGXVKVLYcXDrrXX GgXELDKEIKrSFNP kjQVFcPIjrXXSSc SrSPSPjFGrSjggS PTFcPRSjQPcTFTT    180

    2 TOB2   SVWIDPFEVSYQIGE KGAVKVLYLDDSEGC GAPELDKEIKSSFNP DAQVFVPIGSQDSSL SNSPSPSFGQSP--S PTFIPRSAQPITFTT    178
    3 mTOB2  SVWIDPFEVSYQIGE KGVVKVLYLGDSEAS GTPELDKEIKSSFNP DAQVFVPIGSQDSSL SSSPSPSFGQSP--S PTFIPRSAQPITFTT    178
    4 TOB    SVWIDPFEVSYQIGE KGAVKVLYLDDSEGC GAPELDKEIKSSFNP DAQVFVPIGSQDSSL SNSPSPSFGQSP--S PTFIPRSAQPITFTT    178
    5 TOB1   SVWIDPFEVSYQIGE KGPVKVLYVDDNNEN G-CELDKEIKNSFNP EAQVFMPISDPASSV SSSPSPPFGHSAAVS PTFMPRSTQPLTFTT    179
    6 mTOB1  SVWIDPFEVSYQIGE KGPVKVLYVDDSSET G-CELDKEIKNSFNP EPQVFMPISDPASSV SSSPSPPFGHSAAVS PTFMPRSTQPLTFTT    179



Page 3.1
             181         195 196         210 211         225 226         240 241         255 256         270 
    1 pat-ML AiFAATKFGSTKMKr jGgggXjXXVhXijj gggggggggXrbhXg ggXrrLLKrKjcSXS cHSLXXcjggggggg ggggggggggggggj    270

    2 TOB2   ASFAATKFGSTKMKK GGGAASGGGVASSGA GGQQ-PPQQPRMARS P-TNSLLKHKSLSLS MHSLNFIT------- --------------A    245
    3 mTOB2  ASFAATKFGSTKMKK GGGASGGVSVGGSGA GGQQPPPQQPRMARS P-TKNLLKHKSLSLS MHSLNLIP------- --------------A    246
    4 TOB    ASFAATKFGSTKMKK GGGAASGGGVASSGA GGQQ-PHQQPRMARS P-TNSLLKHKSLSLS MHSLNFIT------- --------------A    245
    5 TOB1   ATFAATKFGSTKMKN SG---RSNKVARTSP ---------INLGL- -NVNDLLKQKAISSS MHSLYGLGLGSQQQP ------QQQQQPAQP    249
    6 mTOB1  ATFAATKFGSTKMKN SG---RSSKVARTSP ---------INLGLT VNVNHLLKQKAISSS VHSLYGLGLGSQQQP QPQPQQQQQQQPSSS    257



Page 4.1
             271         285 286         300 301         315 316         330 331         345 346         360 
    1 pat-ML XPjPggggggggggg ggQgggggggSXLSP NAKEFadgggggPrb gggggrGXjjjjXhX fggXGXjjXrXjjfr fjrXfXXXjXXXXfr    360

    2 TOB2   NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDAADGQGSGTPGP FGGSGAGTCNSSSFD MAQVFGGGANSLFLE    315
    3 mTOB2  NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDGVEGPSTSTTAP FGSGGASTCNSSSFD VSQVFGGGANSLFLE    316
    4 TOB    NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDAADGRAAAPQAR LEAVGLAPATAAALT WPRYLEVVPTASSWR    315
    5 TOB1   PPPPPPP-------- --QQQQQQKTSALSP NAKEFIF-----PNM -----QGQGSSTNGM F--PGDSPLNLSPLQ YSNAFDVFAAYGGLN    317
    6 mTOB1  QPPPPLPQQQQQQPQ QQQQQQQQQTSALSP NAKEFIF-----PNM -----QGQGSSTNGM F--PGDSPLNLSPLQ YSNAFDVFAAYGGLN    335



Page 5.1
             361         375 376         390 391         405 406         420 421         435 436         450 
    1 pat-ML prjFVkGLrdrLNrM QYjrQXFQPgVbAN    389

    2 TOB2   KTPFVEGLSYNLNTM QYPSQQFQPVVLAN    344
    3 mTOB2  KSPFVEGLSYNLNTM QYPNQPFQPVVLAN    345
    4 TOB    RHPFVEGLSYNLNTM QYPSQQFQPVVLAN    344
    5 TOB1   EKSFVDGLNFSLNNM QYSNQQFQP-VMAN    345
    6 mTOB1  EKSFVDGLNFSLNNM QYSNQQFQP-VMAN    363

Sequential Branching Clustering

pat-SB ((((TOB1 1626.05 mTOB1) 993.81 TOB2) 974.81 mTOB2) 972.14 TOB)



Page 1.1
             1            15 16           30 31           45 46           60 61           75 76           90 
    1 pat-SB MQLEIpVALNFIISY LYNKLPRRRXlcFGE ELEpXLnKKYEGHWY PEKPfKGSGFRCaHa GEXVDPVaEXAjKpS GLXakDVRhNcPokL     90

    2 TOB1   MQLEIQVALNFIISY LYNKLPRRRVNIFGE ELERLLKKKYEGHWY PEKPYKGSGFRCIHI GEKVDPVIEQASKES GLDIDDVRGNLPQDL     90
    3 mTOB1  MQLEIQVALNFIISY LYNKLPRRRVNIFGE ELERLLKKKYEGHWY PEKPYKGSGFRCIHV GEKVDPVIEQASKES GLDIDDVRGNLPQDL     90
    4 TOB2   MQLEIKVALNFIISY LYNKLPRRRADLFGE ELERLLKKKYEGHWY PEKPLKGSGFRCVHI GEMVDPVVELAAKRS GLAVEDVRANVPEEL     90
    5 mTOB2  MQLEIKVALNFIISY LYNKLPRRRADLFGE ELERLLRKKYEGHWY PEKPLKGSGFRCVHI GEVVDPVVELAAKRS GLAVEDVRANVPEEL     90
    6 TOB    MQLEIKVALNFIISY LYNKLPRRRADLFGE ELEQALKKKYEGHWY PEKPLKGSGFRCVHI GEMVDPVVELAAKRS GLAVEDVRANVPEEL     90



Page 2.1
             91          105 106         120 121         135 136         150 151         165 166         180 
    1 pat-SB SVWIDPFEVSYQIGE KGXVKVLYcXDrrXX GgXELDKEIKrSFNP kjQVFcPIjrXXSSc SrSPSPjFGrSjggS PTFcPRSjQPcTFTT    180

    2 TOB1   SVWIDPFEVSYQIGE KGPVKVLYVDDNNEN G-CELDKEIKNSFNP EAQVFMPISDPASSV SSSPSPPFGHSAAVS PTFMPRSTQPLTFTT    179
    3 mTOB1  SVWIDPFEVSYQIGE KGPVKVLYVDDSSET G-CELDKEIKNSFNP EPQVFMPISDPASSV SSSPSPPFGHSAAVS PTFMPRSTQPLTFTT    179
    4 TOB2   SVWIDPFEVSYQIGE KGAVKVLYLDDSEGC GAPELDKEIKSSFNP DAQVFVPIGSQDSSL SNSPSPSFGQSP--S PTFIPRSAQPITFTT    178
    5 mTOB2  SVWIDPFEVSYQIGE KGVVKVLYLGDSEAS GTPELDKEIKSSFNP DAQVFVPIGSQDSSL SSSPSPSFGQSP--S PTFIPRSAQPITFTT    178
    6 TOB    SVWIDPFEVSYQIGE KGAVKVLYLDDSEGC GAPELDKEIKSSFNP DAQVFVPIGSQDSSL SNSPSPSFGQSP--S PTFIPRSAQPITFTT    178



Page 3.1
             181         195 196         210 211         225 226         240 241         255 256         270 
    1 pat-SB AiFAATKFGSTKMKr jGgggXjXXVhXijj gggggggggXrbhXg ggXrrLLKrKjcSXS cHSLXXcjggggggg ggggggggggggggj    270

    2 TOB1   ATFAATKFGSTKMKN SG---RSNKVARTSP ---------INLGL- -NVNDLLKQKAISSS MHSLYGLGLGSQQQP ------QQQQQPAQP    249
    3 mTOB1  ATFAATKFGSTKMKN SG---RSSKVARTSP ---------INLGLT VNVNHLLKQKAISSS VHSLYGLGLGSQQQP QPQPQQQQQQQPSSS    257
    4 TOB2   ASFAATKFGSTKMKK GGGAASGGGVASSGA G-GQQPPQQPRMARS P-TNSLLKHKSLSLS MHSLNFIT------- --------------A    245
    5 mTOB2  ASFAATKFGSTKMKK GGGASGGVSVGGSGA GGQQPPPQQPRMAR- SPTKNLLKHKSLSLS MHSLNLIP------- --------------A    246
    6 TOB    ASFAATKFGSTKMKK GGGAASGGGVASSGA -GGQQPHQQPRMAR- SPTNSLLKHKSLSLS MHSLNFIT------- --------------A    245



Page 4.1
             271         285 286         300 301         315 316         330 331         345 346         360 
    1 pat-SB XPjPggggggggggg ggQgggggggSXLSP NAKEFadgggggPrb gggggrGXjjjjXhX fXjXjXXXXrjXXfr XjgggrVfjjXjggg    360

    2 TOB1   PPPPPPP-------- --QQQQQQKTSALSP NAKEFIF-----PNM -----QGQGSSTNGM FPGDSPLNLSPLQYS NAF--DVFAAYG---    314
    3 mTOB1  QPPPPLPQQQQQQPQ QQQQQQQQQTSALSP NAKEFIF-----PNM -----QGQGSSTNGM FPGDSPLNLSPLQYS NAF--DVFAAYG---    332
    4 TOB2   NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDAADGQGSGTPGP FGGSGAGTCNSSSFD MA---QVFGGGANSL    312
    5 mTOB2  NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDGVEGPSTSTTAP FGSGGASTCNSSSFD VS---QVFGGGANSL    313
    6 TOB    NPAP----------- --Q-------SQLSP NAKEFVYNGGGSPSL FFDAADGRAAAPQAR LEAVGLAPATAAALT WPRYLEVVPTAS---    312



Page 5.1
             361         375 376         390 391         405 406         420 421         435 436         450 
    1 pat-SB XfrprjFVkGLrdrL NrMQYjrQXFQPgVb AN    392

    2 TOB1   GLNEKSFVDGLNFSL NNMQYSNQQFQP-VM AN    345
    3 mTOB1  GLNEKSFVDGLNFSL NNMQYSNQQFQP-VM AN    363
    4 TOB2   FLEKTPFVEGLSYNL NTMQYPSQQFQPVVL AN    344
    5 mTOB2  FLEKSPFVEGLSYNL NTMQYPNQPFQPVVL AN    345
    6 TOB    SWRRHPFVEGLSYNL NTMQYPSQQFQPVVL AN    344