Recent Selected Publications

Complete publication list can be found in PubMed.

Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. (2015) " Ubl/ubiquitin switch in the activation of Parkin. " EMBO J. 34(20):2492-505.

Wong K, Kozlov G, Zhang Y, Gehring K (2015) " Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism. " J Biol Chem. 290(41):24727-37.

Li X, Gehring K. (2015) " Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases. " Mov Disord. 30(12):1610-9.

Muñoz-Escobar J, Matta-Camacho E, Kozlov G, Gehring K. (2015) " The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding. " J Biol Chem. 290(37):22841-50.

Seirafi M, Kozlov G, Gehring K. (2015) " Parkin structure and function. " FEBS J. 2015 Jun;282(11):2076-88.

Li X, Ménade M, Kozlov G, Hu Z, Dai Z, McPherson PS, Brais B, Gehring K. (2015) " High-Throughput Screening for Ligands of the HEPN Domain of Sacsin. " PLoS One. 10(9):e0137298.

(2014) " Phosphorylated ubiquitin: a new shade of PINK1 in Parkin activation. " Cell Res. 2014 Sep;24(9):1025-6.

Xie J, Kozlov G, Gehring K. (2014) " The "tale" of poly(A) binding protein: The MLLE domain and PAM2-containing proteins. " Biochim Biophys Acta. 1839(11):1062-8.

Bastos-Aristizabal S, Kozlov G, Gehring K. (2014) " Structural insight into the dimerization of human protein disulfide isomerase. " Protein Sci. 23(5):618-26.

Bastos-Aristizabal S, Kozlov G, Gehring K. (2014) " Structure of the substrate-binding b' domain of the Protein Disulfide Isomerase-Like protein of the Testis. " Sci Rep. 4:4464.

Gulerez IE, Gehring K. (2014) " X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases. " Methods. 65(2):175-83.

Safaee N, Noronha AM, Rodionov D, Kozlov G, Wilds CJ, Sheldrick GM, Gehring K. (2013) " Structure of the Parallel Duplex of Poly(A) RNA: Evaluation of a 50 Year-Old Prediction. " Angew Chem Int Ed Engl. 52(39):10370-3.

Trempe JF, Sauvé V, Grenier K, Seirafi M, Tang MY, Ménade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K. (2013) " Structure of parkin reveals mechanisms for ubiquitin ligase activation. " Science. 340(6139):1451-5.

Vinaik R, Kozlov G, Gehring K. (2013) " Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding. " PLoS One. 8(4):e62021.

Safaee N, Kozlov G, Noronha AM, Xie J, Wilds CJ, Gehring K. (2012) " Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G. " Mol Cell. 48(3):375-86.

Matta-Camacho E, Kozlov G, Ménade M, Gehring K. (2012) " Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase. " Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 10):1158-63.

Jansen G, Määttänen P, Denisov AY, Scarffe L, Schade B, Balghi H, Dejgaard K, Chen LY, Muller WJ, Gehring K, Thomas DY. (2012) " An interaction map of endoplasmic reticulum chaperones and foldases. " Mol Cell Proteomics. 11(9):710-23.

Gulerez IE, Kozlov G, Rosenauer A, Gehring K. (2012) " Structure of the third catalytic domain of the protein disulfide isomerase ERp46. " Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 4):378-81.

Girard M, Larivire R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EG, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP, McPherson PS. (2012) " Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). " Proc Natl Acad Sci U S A. 109(5):1661-6.

Fan AC, Kozlov G, Hoegl A, Marcellus RC, Wong MJ, Gehring K, Young JC. (2011) " Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism. " J Biol Chem. 286(37):32208-19.

Pocanschi CL, Kozlov G, Brockmeier U, Brockmeier A, Williams DB, Gehring K. (2011) " Structural and functional relationships between the lectin and arm domains of calreticulin. " J Biol Chem. 286(31):27266-77.

Kozlov G, Denisov AY, Girard M, Dicaire MJ, Hamlin J, McPherson PS, Brais B, Gehring K. (2011) " Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). " J Biol Chem. 286(23):20407-12.

Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ. (2011) " La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. " Mol Cell Biol. 31(3):542-56.

Määttänen P, Gehring K, Bergeron JJ, Thomas DY. (2010) " Protein quality control in the ER: the recognition of misfolded proteins. " Semin Cell Dev Biol. 21(5):500-11.

Kozlov G, Määttänen P, Thomas DY, Gehring K. (2010) " A structural overview of the PDI family of proteins. " FEBS J. 277(19):3924-36.

Kozlov G, Safaee N, Rosenauer A, Gehring K. (2010) " Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. " J Biol Chem. 285(18):13599-606.

Barelier S, Pons J, Gehring K, Lancelin JM, Krimm I. (2010) " Ligand specificity in fragment-based drug design. " J Med Chem. 53(14):5256-66.

Kozlov G, Pocanschi CL, Rosenauer A, Bastos-Aristizabal S, Gorelik A, Williams DB, Gehring K. (2010) " Structural basis of carbohydrate recognition by calreticulin. " J Biol Chem. 2010 Dec 3;285(49):38612-20.

Kozlov G, Ménade M, Rosenauer A, Nguyen L, Gehring K. (2010) " Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein. " J Mol Biol. 397(2):397-407.

Riedinger C, Boehringer J, Trempe JF, Lowe ED, Brown NR, Gehring K, Noble ME, Gordon C, Endicott JA. " Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. " J Biol Chem. 285(44):33992-4003.

Liu Q, Moldoveanu T, Sprules T, Matta-Camacho E, Mansur-Azzam N, Gehring K. (2010) " Apoptotic regulation by MCL-1 through heterodimerization. " J Biol Chem. 285(25):19615-24.

Kozlov G, Bastos-Aristizabal S, Määttänen P, Rosenauer A, Zheng F, Killikelly A, Trempe JF, Thomas DY, Gehring K. (2010) " Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. " J Biol Chem. 285(46):35551-7.

Matta-Camacho E, Kozlov G, Li FF, Gehring K. (2010) " Structural basis of substrate recognition and specificity in the N-end rule pathway. " Nat Struct Mol Biol. 17(10):1182-7.

Kozlov G, Gehring K. (2010) " Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. " PLoS One. 5(4):e10169.

Denisov AY, Määttänen P, Dabrowski C, Kozlov G, Thomas DY, Gehring K. (2009) " Solution structure of the bb' domains of human protein disulfide isomerase. " FEBS J. 276(5):1440-9.

Trempe JF, Chen CX, Grenier K, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA. (2009) " SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. " Mol Cell. 36(6):1034-47.

Zhang Y, Kozlov G, Pocanschi CL, Brockmeier U, Ireland BS, Määttänen P, Howe C, Elliott T, Gehring K, Williams DB. (2009) " ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity. " J Biol Chem. 284(15):10160-73.

Kozlov G, Määttänen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K. (2009) " Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72. " Structure. 17(5):651-9.

Martineau Y, Derry MC, Wang X, Yanagiya A, Berlanga JJ, Shyu AB, Imataka H, Gehring K, Sonenberg N. (2008) " Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. " Mol Cell Biol. 28(21):6658-67.

Moldoveanu T, Gehring K, & Green DR. (2008) " Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. " Nature, 456(7220): 404-408.

Prakesch M, Denisov AY, Naim M, Gehring K, Arya P. (2008) " The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. " Bioorg Med Chem. 16(15):7443-9.

Ritter B, Denisov AY, Philie J, Allaire PD, Legendre-Guillemin V, Zylbergold P, Gehring K, & McPherson PS. (2007)" The NECAP PHear domain increases clathrin accessory protein binding potential. " EMBO J., 26(18): 4066-77.

Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, & Gehring K. (2007) " Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. " Mol. Cell, 27(3): 474-85.

Siddiqui N, Osborne MJ, Gallie DR, & Gehring K. (2007) " Solution Structure of the PABC Domain from Wheat Poly (A)-Binding Protein: An Insight into RNA Metabolic and Translational Control in Plants. " Biochemistry, 46(14): 4221-31.

Denisov AY, Sprules T, Fraser J, Kozlov G, & Gehring K. (2007) " Heat-induced dimerization of BCL-xL through alpha-helix swapping. " Biochemistry, 46(3):734-40.

Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, & Gehring K. (2006) " The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. " Mol. Cell, 24(5):677-88.

Kozlov G, Maattanen P, Schrag JD, Pollock S, Cygler M, Nagar B, Thomas DY, & Gehring K. (2006) " Crystal Structure of the bb' Domains of the Protein Disulfide Isomerase ERp57. " Structure, 14(8):1331-9.

Lim NS, Kozlov G, Chang TC, Groover O, Siddiqui N, Volpon L, De Crescenzo G, Shyu AB, & Gehring K. (2006) " Comparative peptide-binding studies of PABC domains from the E3 ubiquitin ligase HYD and poly(A)-binding protein: implications for HYD function. " J. Biol. Chem., 281(20):14376-82.

Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, & Gehring K. (2006) " Structural model of the BCL-w - BID peptide complex and its interactions with phospholipid micelles. " Biochemistry, 45(7):2250-6.

Kozlov G, Vavelyuk O, Minailiuc O, Banville O, Gehring K, & Ekiel I. (2006) " Solution structure of a two-repeat fragment of major vault protein. " J. Mol. Biol., 356(2):444-52.

Volpon L, D'Orso I, Young CR, Frasch AC, & Gehring K. (2005) " NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding. " Biochemistry, 44(10):3708-17.

Ritter B, Denisov AY, Philie J, Deprez C, Tung EC, Gehring K, & McPherson PS. (2004) " Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. " EMBO J., 23(19):3701-10.

Pollock S, Kozlov G, Pelletier MF, Trempe JF, Jansen G, Sitnikov D, Bergeron JJ, Gehring K, Ekiel I, & Thomas DY. (2004) " Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system. " EMBO J., 23(5):1020-9.

Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, & Gehring K. (2004) " Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. " EMBO J., 23(2):272-81.

Kozlov G, Lee J, Elias D, Gravel M, Gutierrez P, Ekiel I, Braun PE, & Gehring K. (2003) " Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily. ", J. Biol. Chem., 278(46):46021-8.

Denisov A.Yu., Hannoush R.N., Gehring K., & Damha M.J. (2003) " A novel RNA motif based on the structure of unusually stable 2',5'-linked r(UUCG) loops ", J. Am. Chem. Soc., 125(38):11525-31.

Denisov A.Yu., Madiraju M.S.R., Chen G., Khadir A., Beauparlant P., Attardo G., Shore G.C. & Gehring K. (2003) " Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix ", J. Biol. Chem., 278(23):21124-8.

Sprules T., Green N., Featherstone M. & Gehring K. (2003) " Lock and key binding of the HOX YPWM peptide to the PBX homeodomain", J. Biol. Chem. 278(2):1053-8.

Trempe J-F., Morin F.G., Xia Z., Marchessault R.H. & Gehring K. (2002) "Characterization of polyacrylamide-stabilized Pfl phage liquid crystals for protein NMR spectroscopy", J. Biomol. NMR. 22(1):83-7.

Kozlov G., Siddiqui N., Coillet-Matillon S., Trempe J-F., Ekiel I., Sprules T. & Gehring K.(2002) " Solution structure of the orphan PABC domain from Saccharomyces cerevisiae poly(A)-binding protein", J. Biol. Chem. 277(25):22822-8.

A. Yee, X. Chang, A. Pineda-Lucena, B. Wu, A. Semesi, B. Le, T. Ramelot, G. M. Lee, S. Bhattacharyya, P. Gutierrez, A. Denisov, C. Lee, J. R. Cort, G. Kozlov, J. Liao, G. Finak, L. Chen, D. Wishart, W. Lee, L. P. McIntosh, K. Gehring, M.A. Kennedy, A. M. Edwards & C. H. Arrowsmith (2002) "An NMR approach to structural proteomics ", Prog. Natl. Acad. Sci. USA 99(4):1825-1830.

Denisov, A.Yu., Noronha, A.M., Wilds, C.J., Trempe, J.-F., Pon, R.T., Gehring, K. & Damha, M.J. (2001) "Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids", Nucleic Acids Res. 29(21):4284-4293.

Trempe, J.-F., Wilds, C., Denisov, A.Yu., Pon, R.T., Damha, M. & Gehring, K. (2001) "NMR solution structure of an oligonucleotide hairpin with a 2'F-ANA/RNA stem: implications for RNase H specificity toward DNA/RNA hybrid duplexes", J. Am. Chem. Soc. 123(21):4896-4903.

Kozlov, G., Trempe, J.-F., Khaleghpour, K., Kahwajian, A., Ekiel, I. & Gehring K. (2001) "Structure and function of the C-terminal PABC domain of human poly(A) binding protein", Proc. Natl. Acad. Sci. USA 98(8):4409-4413.

Christendat D., Yee A., Dharamsi A., Kluger Y., Savchenko A., Cort J.R., Booth V., Mackereth C.D., Saridakis V., Ekiel I., Kozlov G.,Maxwell K.L., Wu N., McIntosh L.P., Gehring K., Kennedy M.A., Davidson A.R., Pai E.F.,Gerstein M., Edwards A.M. & Arrowsmith C.H. (2000) "Structural proteomics of an archeaon", Nat. Struct. Biol. 7(10):903-909.

Saragovi H.U. & Gehring K. (2000) "Development of pharmacological agents for targeting neurotrophins and their receptors",Trends Pharmacol. Sci. 21(3):93-98.

Sprules, T., Greene, N., Featherstone, M. & Gehring, K. (2000) "Conformational changes in the PBX homeodomain and C-terminal extension upon binding DNA and a HOXA1 YPWM peptide", Biochemistry 39(32):9943-9950.

Kozlov, G., Ekiel, I., Beglova, N., Yee, A., Dharamsi, A., Engel, A., Siddiqui, N., Nong, A. & Gehring, K. (2000) "Rapid fold and structure determination of the archaeal translation elongation factor 1 beta from Methanobacterium thermoautotrophicum ", J. Biomol. NMR 17(3):187-194.

Beglova, N., Maliartchouk, S., Ekiel, I., Saragovi, U. & Gehring, K.(2000) "Design and Solution Structure of Functional Peptide Mimetics of Nerve Growth Factor", J. Med. Chem. 43(19):3530-3540.

Kozlov, G., Gehring, K. & Ekiel, I. (2000) "Solution Structure of the PDZ2 Domain from Human Phosphatase hPTP1E and Its Interactions with C-Terminal Peptides from the Fas Receptor", Biochemistry 39(10):2572-2580.